Calcium Alpha-ketoglutarate (Ca-AKG)

1. Introduction

Calcium Alpha-Ketoglutarate (Ca-AKG) is a scientifically formulated salt compound that combines alpha-ketoglutarate (AKG)—a key metabolic intermediate in the Krebs cycle (TCA cycle)—with bioavailable calcium ions. This dual-action supplement supports cellular energy production, metabolic health, muscle recovery, and bone strength, making it valuable for athletes, longevity researchers, and health-conscious individuals.

Presented in a fine, water-soluble powder form, Ca-AKG offers excellent bioavailability and convenient dosing flexibility for optimal supplementation.

2. Physicochemical Properties of Calcium Alpha-Ketoglutarate

• Chemical Formula: C₅H₄CaO₅ (calcium salt of α-ketoglutaric acid)

• Molecular Weight: 184.16 g/mol

• Appearance: White to off-white crystalline powder

• Solubility: Highly soluble in water (~50 g/100 mL at 20°C), slightly soluble in ethanol

• pH (1% solution): ~7.0–8.5 (neutral to slightly alkaline)

• Thermal Stability: Stable at room temperature; decomposes at high temperatures (>200°C)

• Chelated Structure: Calcium is bound to AKG, enhancing mineral absorption compared to inorganic calcium salts (e.g., calcium carbonate).

• Metabolic Reactivity: AKG acts as a critical anaplerotic agent, replenishing TCA cycle intermediates for efficient ATP production.

• Hygroscopicity: Low moisture absorption when stored properly (recommended in airtight containers).

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3. Key Benefits & Applications of Calcium Alpha-Ketoglutarate

   Enhanced Energy & Mitochondrial Function

• AKG is a central substrate in the TCA cycle, facilitating ATP synthesis and improving cellular energy metabolism.

• Supports mitochondrial biogenesis and may reduce oxidative stress via NAD+/NADH balance.

   Anti-Aging & Longevity Support

• Modulates mTOR and AMPK pathways (animal studies suggest lifespan extension).

• Precursor for glutathione synthesis, enhancing antioxidant defense.

   Muscle Recovery & Exercise Performance

• Reduces ammonia accumulation during exercise, delaying fatigue.

• May promote protein synthesis by supporting glutamine/glutamate metabolism.

  Bone Health & Calcium Supplementation

• Provides highly bioavailable calcium (superior to carbonate/citrate in some studies).

• Synergistic with vitamin D3 and magnesium for bone mineral density.

 Metabolic & Cardiovascular Support

• Enhances nitric oxide (NO) production, improving endothelial function.

• Potential role in glucose metabolism via TCA cycle modulation.

4. Recommended Usage & Formulation of Calcium Alpha-Ketoglutarate

• Dosage Range: 1–3 g/day, split into 1–2 servings (e.g., pre/post-workout or with meals).

• Optimal Delivery:

  • Powder: Mixes easily in water, juices, or smoothies (neutral taste).

  • Capsules/Tablets: Convenient for precise dosing.

• Synergistic Combinations:

  • With Vitamin D3/K2: Maximizes calcium absorption and bone targeting.

  • With Magnesium & L-Glutamine: Enhances muscle recovery.

5. Safety & Stability Considerations

• Safety Profile:

  • Generally recognized as safe (GRAS) at recommended doses.

  • Rare side effects: Mild GI discomfort (e.g., bloating) at high doses.

• Contraindications:

  • Hypercalcemia or kidney dysfunction (monitor calcium intake).

  • Caution with calcium-sensitive medications (e.g., tetracyclines, thyroid drugs).

• Storage:

  • Keep in a cool, dry place (15–25°C) in airtight packaging to prevent moisture absorption.

  • Shelf life: Typically 24 months if stored properly.

6. Specification of Calcium Alpha-Ketoglutarate

Calcium Alpha-Ketoglutarate (Ca-AKG) Powder is a multifunctional nutraceutical leveraging the metabolic power of AKG and the structural benefits of calcium. Its excellent solubility, neutral taste, and high bioavailability make it ideal for:

• Athletes seeking endurance/recovery support.

• Aging populations targeting cellular health.

• General wellness applications (energy, bone, and metabolic optimization).

For optimal results, integrate into a balanced diet and active lifestyle, and consult a healthcare provider for personalized dosing.

Interested in formulating with Ca-AKG?
Request technical specifications (TDS/MSDS) from suppliers for R&D or commercial use!

Link:  Kangyo’s product list